KNOVA Prenatal Screening | Fulgent Australia

Physician and patient smiling while talking together

Beyond Expectations:
Prenatal Screening for the Future

KNOVA is an advanced prenatal screening test identifying pregnancies at high risk for certain severe, early-onset disorders. Using only a simple blood draw that can be collected as early as 10 weeks into a pregnancy, KNOVA leverages cutting-edge technology to examine placental DNA from the pregnant person's blood to look for signs of genetic conditions that could affect their baby's health. KNOVA can also predict a baby's sex.

This type of testing is called prenatal cell-free DNA screening and may also be referred to as non-invasive prenatal testing (NIPT) or non-invasive prenatal screening (NIPS).

As a screening test, KNOVA identifies pregnancies at high risk for certain conditions. KNOVA is not diagnostic - if a high-risk pregnancy is identified, further diagnostic testing (during pregnancy or postnatally) is required to know whether the baby is affected. Decisions about a pregnancy should not be made using the KNOVA test alone. Rather, this test should be used to help identify potential risk at an early stage.

Comprehensive Coverage, More Informed Choices

KNOVA provides more comprehensive coverage, reporting on more genetic conditions, than other prenatal screens. Analysis that goes beyond the standard chromosomal conditions means more knowledge for families and their physicians.

KNOVA screens for:

6 Types of Autosomal Trisomies	Trisomy 13, Trisomy 15, Trisomy 16, Trisomy 18, Trisomy 21*, Trisomy 22
4 Types of Sex Chromosome Aneuploidies	45,X; 47,XXX; 47,XXY; 47,XYY
12 Chromosomal Microdeletions	1p36 del, 2q33 del, 4p16 del, 5p15 del, 8q23q24 del, 9p del, 11q23q25 del, 15q11.2-q13 del, 17p11.2 del, 18p del, 18q22q23 del, 22q11.2 del
56 Single Genes Associated with over 30 monogenic conditions, expanding the scope of prenatal screening to encompass a broader spectrum of genetic disorders.	ASXL1, BRAF, CBL, CD96, CDKL5, CHD7, COL10A1, COL11A1, COL1A1, COL1A2, COL2A1, EBP, EFNB1, ERF, FGFR1, FGFR2, FGFR3, FLNB, FREM1, GLI3, HDAC8, HNRNPK, HRAS, KAT6B, KMT2D, KRAS, LMNA, MAP2K1, MAP2K2, MECP2, NIPBL, NRAS, NSD1, NSDHL, PTPN11, RAD21, RAF1, RIT1, RUNX2, SHOC2, SKI, SLC25A24, SMC1A, SMC3, SNRPB, SOS1, SOS2, SOX9, SPECC1L, STAT3, TCF12, TRAF7, TSC1, TSC2, TWIST1, ZIC1

*Twin pregnancies and egg donor-derived singleton pregnancies can only receive testing for these three trisomies (13, 18, and 21) with our CORE Aneuploidy Panel. Our FULL KNOVA panel is appropriate for singleton pregnancies only; testing cannot be performed for cases with a history of egg donor, fetal demise, vanishing twin, or reduction.

Unparalleled Accuracy and Detection*

Concurrent Analysis

Evaluates for pregnancies at high risk for fetal pathogenic variants on both the chromosomal and single-gene levels

Gold Standard Performance

98.5% sensitivity and 99.3% specificity relative to standard diagnostics (based on a study of 1000+ participants at increased risk for fetal genetic conditions)

Higher Detection Rate

Inclusion of targeted monogenic conditions led to a 60.7% increase in detection rate

*Zhang J, Wu Y, Chen S, Luo Q, Xi H, Li J, et al. Prospective prenatal cell-free DNA screening for genetic conditions of heterogenous etiologies. Nat Med. 2024 Feb;30(2):470-479. doi: 10.1038/s41591-023-02774-x.

Simple, Streamlined Process

The KNOVA testing process is straightforward and convenient, prioritising comfort and peace of mind:

Complete Forms

Download and fill out the test request and informed consent forms (available below).

Collect Sample

Sample collection kits are available upon request by a clinician.

Ship

Send sample and completed forms to:
Fulgent Australia,
Level 1, 182 Fullarton Road
Dulwich, South Australia 5065

Receive Report

Results will be available within 2-3 weeks.

DOWNLOAD TEST REQUEST FORM

DOWNLOAD CONSENT FORM

KNOVA provides expectant parents with the information they need to make proactive decisions about their pregnancy care.

Get in touch today to learn more about KNOVA.

Eligibility

Patients eligible for the FULL KNOVA panel include those with singleton pregnancies of at least 10 weeks gestation.
Twin pregnancies and IVF pregnancies using an egg donor are only eligible for our CORE KNOVA panel, which includes trisomies 13, 18, and 21 only.
Higher order multiples (triplets and higher) are not eligible for this test.
Testing cannot be performed for cases with a history of egg donor, fetal demise, vanishing twin, or reduction.